Diffusion-weighted and Dynamic Contrast-enhanced MRI of Metastatic Bone Tumors: Correlation of the Apparent Diffusion Coefficient, K and ve values
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چکیده
Diffusion-weighted magnetic resonance imaging (DW-MRI) is a novel imaging technique that reflects microscopic water diffusion using a pair of strong diffusion gradients. It was developed to map the apparent diffusion coefficient (ADC) (1). Parallel to the development of DW-MRI, there have been advances in Dynamic contrast-enhanced MRI (DCEMRI). Using the MRI signal and pharmacokinetic models, parameters such as the volume transfer constant of the contrast agent (K) and the extravascular extracellular volume fraction (ve) can be obtained. This allows a qualitative and quantitative evaluation of the angiogenic characteristics of tumors (2-4). There have been many studies regarding the usefulness of ADC Values, K or ve in differentiating benign from malignant lesions in various organs (510). The ADC value correlates inversely with tissue cellularity. K and ve can characterize tissue vasculaINTRODUCTION
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